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HdTr0+(R^ 0000035692 00000 n Risk of developing potentially life-threatening anaphylactic reactions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Delay administration of the initial therapeutic Infed dose until 1 hour or more after the test dose. Administer daily doses of no more than 2 mL of Infed until the total required dose is administered. Fatal reactions have also occurred in situations where the test dose was tolerated. Am J Kid Dis. (5.1) 0000026302 00000 n INFeD should be used with caution in individuals with histories of significant allergies and/or asthma. The easiest-to-prepare dilute solution (iron dextran, benzyl alcohol, and sterile water for injection) was stable for three months; stability was greater when refrigerated. .0.34% Advise the patient to consult a healthcare provider before taking any other iron containing products as this may cause serious side effects [see Warnings and Precautions (5.4)]. J Pediatr Pharmacol Ther. Crosses the placenta and small amounts of iron apparently reach the fetus. The test dose should be administered in the same recommended test site and by the same technique as described in the last paragraph of this section. . Reticulocyte count will increase in 3-4 days and peak in 7-10 days. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. There are no data on the effects of iron dextran in breastfed infants or effects on milk production. 7.1 Drug/Laboratory Test Interactions CAREFULLY BEFORE ACCESSING OR USING THIS SITE. The stability of injectable medications after reconstitution is presented. 0000002072 00000 n NOTE: Do not mix Infed with other medications or add to parenteral nutrition solutions for intravenous infusion. Respiratory, thoracic and mediastinal disorders: Respiratory arrest, dyspnea, bronchospasm, wheezing. 0000013099 00000 n This site needs JavaScript to work properly. . xb```f``= @Q#3108-. 0000010855 00000 n To avoid injection or leakage into subcutaneous tissue, use Z-track injection technique (i.e., firmly push aside subcutaneous tissue over the site of injection before inserting the needle). Removal of Iron Dextran by Hemodialysis: An In Vitro Study. Written by ASHP. PDF INFeD (IRON DEXTRAN INJECTION USP) Rx only Revised: September 2020 Recommended formula (where Wt = patient's weight in kg and Hbo = observed hemoglobin in g/dL) for calculating total dosage of iron dextran injection (in mL): Use the following formula to calculate required total dosage of iron dextran injection (in mL): Infants weighing <5 kg (11 lbs): Maximum daily dosage is 25 mg of iron. To avoid injection or leakage into the subcutaneous tissue, a Z-track technique (displacement of the skin laterally prior to injection) is recommended. All pregnancies have a background risk of birth defects, loss, or other adverse outcomes. 0000039715 00000 n . Administration Package insert / product label JLdddd0]`kig?yLm[}6:|Mm-g;b%&?,X,|&Y_}:|!'l%B%e]oJ\}v8l="[;`_#3B]v4ysnp6p3oQd+j_07(+g_Co;haE+1bk+|e>inBko686Jf?2o_>qfETmP@5(C7b$;HvqW!Vb(FNz& Prior to the first intravenous Infed therapeutic dose, administer an intravenous test dose of 0.5 mL [see BOXED WARNING and Warnings and Precautions (5.1)]. [See USP Controlled Room Temperature]. (See Sensitivity Testing under Dosage and Administration.) American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. infed stability after reconstitution - womensbond.com (See Boxed Warning.) Azacitidine - Vidaza - GlobalRPH a. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Infed: Package Insert / Prescribing Information - Drugs.com Br Med J (Clin Res Ed). The circulating iron is bound to the available protein moieties to form hemosiderin or ferritin, or to a lesser extent to transferrin. 4. Brand names: Dexferrum, INFeD . Patheon Italia S.p.A. General disorders and administration site conditions: chest pain, chest tightness, weakness, malaise, febrile episodes, chills, shivering, sterile abscess, atrophy/fibrosis (intramuscular injection site), brown skin and/or underlying tissue discoloration (staining), soreness or pain at or near intramuscular injection sites, swelling, inflammation. Use of 5% dextrose injection instead of 0.9% sodium chloride injection may be associated with a higher incidence of local pain and phlebitis. *Table values were calculated based on a normal adult hemoglobin of 14.8 g/dl for weights greater than 15 kg (33 lbs) and a hemoglobin of 12.0 g/dl for weights less than or equal to 15 kg (33 lbs). Animal Data Each days dose should not exceed 0.5 mL (25 mg of iron) for infants with body weight under 5 kg (11 lbs); 1 mL (50 mg of iron) for children with body weight under 10 kg (22 lbs); and 2 mL (100 mg of iron) for other patients. AHFS DI Essentials. Concomitant use of angiotensin-converting enzyme inhibitor drugs may increase the risk for anaphylactic-type reactions to an iron dextran product. Infed is contraindicated in patients who have demonstrated a previous hypersensitivity to iron dextran [see Warnings and Precautions (5.1)]. Bonnie E. Kirschenbaum, M.S., Clifton J. Latiolais, Sc.D., Stability of injectable medications after reconstitution, American Journal of Hospital Pharmacy, Volume 33, Issue 8, 1 August 1976, Pages 767791, https://doi.org/10.1093/ajhp/33.8.767. 8.2 Lactation PMC Such reactions may be immediate or delayed. 0000003708 00000 n Curr Opin Clin Nutr Metab Care. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Absorbed slowly from the site of IM injection, principally through the lymphatic system; 60% of an IM dose after 3 days, up to 90% after 13 weeks; and the remainder gradually absorbed over a period of several months or longer. Calculate the Infed dose based upon Table 1 and formulas below. Alternatively, the total dose may be calculated using the formulas below: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target hemoglobin in g/dL [Normal hemoglobin (males and females) for body weight over 15 kg (33 lbs) is 14.8 g/dL. Use the following formula to calculate required total iron dextran dosage in mL: 0.02 blood loss (in mL) hematocrit (expressed as a decimal fraction) = total dosage of iron dextran injection (mL). A.YGtT~Ud!$8 d|Ey[9l]^Z.d,{Ah>=1LfC6= Lc3I`hOf2!*sXk!dPz9.UZJe|6xsd_nMS]UYG4@GCj_'8m$7$U |_6%$yf