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Afirma BRAF V600E o Afirma BRAF testing may be considered for either GSC or FNA suspicious or malignant results. I scheduled the surgery for June 3rd but now I'm apprehensive because I don't want to have surgery if there's a chance of this to be benign. Recommended surgery for suspicious cancer cells. Also difficult is the reaction from others. Long-Term Outcomes of Thyroid Nodule AFIRMA GEC Testing and Literature Review: An Institutional Experience. I've read a lot about this test (both good and bad). I don't understand the results , I thought that if the result is Benign it means you have no cancer genes and it is 95% sure you won't get cancer . The authors concluded that a GEC suspicious test result may include noninvasive follicular variant papillary thyroid cancer as well as classical papillary thyroid cancer. Veracyte Announces New Data Suggesting Afirma Testing Can Help The Afirma test results came back Benign on left side and Suspicious 40% on the right side . Frontiers | Analytical Verification Performance of Afirma Genomic However, the results are not conclusive. Careers. Here n this 2014 discussion member Olivia-T who was 69 when she posted this and had hurthle cell neoplasm that tripled in size in 10 months,and got a 40% suspicious from the Afirma test,and did post a follow up that did turn out to have thyroid cancer,says here that her oncologist said that her last two patients who had surgery also because of the 40% suspicious for cancer DNA test turned out to have benign tumors. PDF Afirma Thyroid Cancer Classifier Tests - evicore.com These results do not change the risk of malignancy of the (ROM) of the Afirma GSC suspicious result." Epub 2020 May 21. A 36% Increase in Specificity With Afirma GSC Versus Older Test . Hi, I am joining this group because I was recommended surgery.. I had that one sent to Afirma, and it came back indeterminate on cytopathology again, benign on GEC. GEC's SE and SP among studies ranged from 78.0 to 100% and 7.7 to 51.7%, respectively. I also recently found *another* article written by an endocrine surgeon Sam Wiseman from the Department of Surgery ,St.Paul's Hospital University Of British Columbia for the site Gland Surgery where he also points out real concerns that half of patients(as I said I know it's more,from all of the people I have found posting on thyroid boards) with benign nodules wrongly classified as "suspicious" by the Afirma test are getting unnecessary thyroid surgery because this Afirma result influenced a lot of endocrinologists and their patients to have the thyroid surgery! FOIA In May 2013 I spoke to Barbara Rath Smith the executive director of The American Thyroid Association and she said she was going to email articles as files to download and she did. After reading many stories, I didn't know what to expect. I heard about the Afirma analysis , spent $5000 on the test and the results are even more confusing !! Which means I would still be paying this amount to the hospital if I didn't pay it to Affirma. Thyroid nodule molecular profiling: The clinical utility of Afirma I'm now 3 days post op and other than some difficulty swallowing and talking loud, I'm feeling great. At first it sounded like only the encapsulated variety was going to be included in the reclassification, but more recently it seems that non-encapsulated and non-invasive FVPTC is also going to be included. Just had TT yesterday. Our new findings show that the real-world experience supports this data, further demonstrating that the likelihood of malignancy in Afirma GSC-suspicious nodules is even greater than what was . This did not surprise me since I had researched "suspicious." Don't get me wrong, it hurts, but I'm able to swallow (soft foods) and talk ok. Hello. Also is anybody here familiar with "Afirma Thyroid Analysis" Would you like email updates of new search results? Thyroid nodule biopsies are used to identify if a nodule is cancerous or determine the risk that a thyroid nodule may be cancerous. At least as accurate as FNA, or that was my understanding. This occurs in 1520% of biopsies and often results in the need for surgery to remove the nodule. One has tested benign on several FNAs, is cystic, and has remained consistent in size. :-). Largest is 2.3(previously 1.8cm in 2014) different test center though. BACKGROUND No one was telling me that. Disclaimer. -38yrs old 2. Afirma GSC(NOT GEC) 50% Suspicious - Thyroid cancer - Inspire Genes: a molecular unit of heredity of a living organism. These gene patterns are better at ruling out thyroid cancer in an indeterminate nodule than confirming cancer. The rate of malignancy in nodules suspicious by Afirma was 18.3% (11/60). I have met with multiple surgeons, and am meeting with the one I am selecting on Friday and wanted some info on what to do, and how to proceed. Epub 2017 Feb 2. On May 8th endocrinologist Dr.Steven P.Hadak who with Dr. David S. Rosenthal co-authored one of these studies for The American Thyroid Association's Clinical Affairs Committee called,Information For Clinician's:Commercially Available Molecular Diagnosis Testing In The Evaluation Of Thyroid Nodule Fine-Needle Aspiration Specimens called me back and was very nice,he even had a patient waiting! Arma XA is not performed on GSC Benign nodules.7 IIIIV Atypia of Undetermined Signicance 2) Partial or Total Thyroidectomy? This site needs JavaScript to work properly. Third, I have no history of thyroid cancer (or any cancer) in my family. Epub 2020 Mar 17. Many endocrinologists have written articles in The American Thyroid Association's journal criticizing the inaccuracies and unrelabilities of this recent Afirma test, the strongest criticism and concern is by endocrinologist of (*50* years!) I called and almost everyone has that risk if it is suspicious. She didn't seem overly concerned based on all my previous records. On surgical resection 82% were benign, with 45% follicular adenoma (FA), and 37% nodular goiter (NG). Afirma Practice Resources Meanwhile I read a recent WSJ article about patients with ACTUAL thyroid cancer being offered a wait and see approach as there are so many issues after surgery--not just discomfort issues like fatigue, weight gain and so forth but also secondary cancers. Used for FNA suspicious nodules (bethesda V-VI) or nodules deemed suspicious by the GSC classifier. The Afirma Xpression Atlas for thyroid nodules and thyroid cancer Rationale: Crosswalk to 81545 ($3,600) 81545 describes the original Afirma classifier; when . Competition Heats Up With Latest Tests for Thyroid Nodules There was no follow up in 13% of cases and 87% were resected (50% lobectomies and 50% total thyroidectomies). Please click on this link below about the woman with a 1-1 and half cm solid hypoechoic nodule who had an inconclusive Fine Needle biopsy which was suspicious as a follicular neoplasm and mine is being called a follicular neoplasm with oncocytic (hurthle cell features) ,this woman had her FNA nodule sample tested by the veractye Afirma Test which is what I had done,the results came back telling her that her that their results on her FNA was highly suspicious and that because of this her endo told her she had an 80% chance of having thyroid cancer and so she had her thyroid out and found out it was benign! The https:// ensures that you are connecting to the My surgeon wants to operate right away stating that these kind of results have a 90% truancy for cancer to be present. PDF Summary of Veracyte Recommendations - CMS After hearing this, I felt a huge kick in my gut and also stupid for getting a second opinion for a fine needle biopsy though I'd ended up with an endo, who wrote articles on the subject. Dr.Hershman then says, In a world where there are unlimited financial resources,both the oncogene and the GEC methods could be applied to all indeterminate nodules,but this approach is not practical currently. Afirma GEC or GSC a gene-expression classifier that identifies biopsies as "benign" or "suspicious," and mir-THYtype an mRNA-based classifier test. I didn't want to live with the risk, especially already being hypo and having nodules on the other side slowly growing. A month ago I had the Afirma test and it came back positive - suspicious for cancer which increased my chance from 5% to 50%. (although it is so small, you can see it in my neck). Next-Generation Molecular Tests for Thyroid Nodules: Which to Use On cytologic evaluation 3.0% of the cases were non diagnostic (ND), 9% benign, 62% AUS, and 26% suspicious for neoplasm (SN). On cytologic evaluation 3.0% of the cases were non diagnostic (ND), 9% benign, 62% AUS, and 26% suspicious for neoplasm (SN). Afirma GSC (NOT GEC) 50% Suspicious Fayadosky Oct 30, 2018 10:56 AM (edited Nov 04) Results came back 50% Suspicious for FN (Follicular Neoplasm) with positive HRAS c.18HRAS c.182A>G (Q61R) Negative for BRAF, RET/ptc1 and ptc3 Any Insights? Neither will talk to the other. t=5283], http://www.thyroidboards.com/showthread.php? Thank you so much! I'm curious, if you had similar biopsy results and had surgery, was your final path malignant or not? 42 year old female. We had a long talk and discussed more conservative options, like a partial thyroidectomy, but no rush. My doctor then sent me to an endocrinologist for a biopsy which came back with atypical but inconclusive results. Once you go down the hole, there are no good statistics to guide you in making rational decisions in an irrational area of medicine - AND as you know, no decisions in medicine in even cut and dried cases are so simple as to have no opposing point of view. I had a biopsy for 4 nodules 2 mos ago. Afirma Genomic Sequencing Classifier and Xpression Atlas - PubMed And the 3rd test was Afirma which came back "suspicious". Now having dodged a few close bullets, I was like wobble head to my new endo's treatment plan which included 100 mci RAI though after reading my path report that I may be at little higher risk with "variant" than most others. I almost want to cancel the surgery. The other side is that I had to have a 2nd biopsy done just to collect cells for AFIRMA. However, the interesting twist was that cancer was not detected on the nodules being monitored, there was a little sucker hidden behind all these years according to my surgeon and this was why the pathologist at my local hosp could not come up with definitive conclusion as he/she was only focused on the biopsied nodules:(